Research Article

Bergamot Polyphenolic Fraction supplementation improves metabolic balance, endothelial function and maximal oxygen uptake in athletes

Rocco Mollace, Micaela Gliozzi, Annamaria Tavernese, Vincenzo Musolino, Cristina Carresi, Miriam Scicchitano, Ernesto Palma, Saverio Nucera, Francesca Bosco, Federica Scarano, Francesca Oppedisano, Alessia Maretta, Jessica Maiuolo, Saverio Muscoli, Santo Gratteri, Francesco Romeo and Vincenzo Mollace*

Published: 10 April, 2018 | Volume 3 - Issue 2 | Pages: 053-061

Background: The study aimed to evaluate the effects of a 4-week Bergamot Polyphenolic Fraction (BPF Gold; Bergamet Sport) supplementation on serum nitric oxide (NO), asymmetric dimethyl-arginine (ADMA), Endopat indices of endothelial function and maximal oxygen uptake (V_ O2max) of athletes.

Methods: The effects of dietary supplementation (BPF Gold, 650 mg twice a day for 4 weeks) and placebo administration on flow-mediated dilatation (via Endopat measurements), serum markers (NO, ADMA), lipid profile, and V_ O2max were analysed in 30 athletes both before and after dietary protocols.

Results: Significant differences between pre- and post-intervention baseline NO levels were observed after BPF Gold dietary protocol. Higher post-intervention baseline NO level was observed after BPF Gold diet compared with placebo. Moreover BPF Gold Sport increased baseline NO concentration (ΔNO). The positive correlation was observed between baseline post-intervention NO concentration and maximal oxygen uptale and also between ΔNO and ΔVO2max in response to BPF Gold supplementation. There was an association between a higher Edopat values of endothelial function and higher V O2max after Bergamet Sport diet compared with lower values of placebo.

Conclusions: These findings suggest that an increase in NO release in response to BPF Gold Sport supplementation may play a central role in cardiovascular adaptive mechanisms and enhanced exercise performance in athletes.

Read Full Article HTML DOI: 10.29328/journal.jsmt.1001027 Cite this Article Read Full Article PDF


Bergamot polyphenolic fraction; Nitric oxide; Endothelial function; Physical exercise


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